Improved diagnosis of tuberculosis in HIV-positive patients using RD1-encoded antigen CFP-10

The RD1-encoded antigen Rv3872 of Mycobacterium tuberculosis as a potential candidate for serodiagnosis of tuberculosis.

Tuberculosis (TB) infections in India account for one-third of the global burden, making it important to develop speedy, cost-effective diagnostic tools. This study evaluated recombinant RD1-encoded antigens of Mycobacterium tuberculosis as tools for serodiagnosis by determining the immunological reactivity of these proteins against sera from healthy, bacille Calmette-Guérin (BCG)-vaccinated an...

Response to M. tuberculosis selected RD1 peptides in Ugandan HIV-infected patients with smear positive pulmonary tuberculosis: a pilot study

BACKGROUND Tuberculosis (TB) is the most frequent co-infection in HIV-infected individuals still presenting diagnostic difficulties particularly in developing countries. Recently an assay based on IFN-gamma response to M. tuberculosis RD1 peptides selected by computational analysis was developed whose presence is detected during active TB disease. Objective of this study was to investigate the ...

Expression and Purification of Recombinant Mycobacterium Tuberculosis (TB) Antigens, ESAT-6, CFP-10 and ESAT- 6/CFP-10 and Their Diagnosis Potential for Detection of TB Patients

BACKGROUND One of the most widely used methods to detect tuberculosis (TB) infection is the tuberculin skin test (TST). The completion of Mycobacterium tuberculosis (M. tuberculosis) genome sequence has led to identification of several antigens that can be utilized for accurate diagnosis and control of TB. The aim of this study was to purify the recombinant M. tuberculosis antigens for the eval...

expression and purification of recombinant mycobacterium tuberculosis (tb) antigens, esat-6, cfp-10 and esat- 6/cfp-10 and their diagnosis potential for detection of tb patients

Use of Cfp-10- Antigen with Fcγ2α Igg for Vaccine against Tuberculosis: Effective or Non-effective?

Tuberculosis (TB), a major public health problem, is a re-emerging challenging through the world. Prevention of this disease is a priority of WHO. Many subunit vaccine have been candidate for vaccination. Evaluating the safety and efficacy of these antigens is the concern of many researchers. This review is discussed efficiency or non-efficiency of CFP-10antigen with Fcγ2α IgG for vaccine desig...